Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases

Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases

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The amygdala plays a major role in the processing of physiologic and behavioral responses to stress and is characterized by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state.Human and animal studies LIVING SALSA showed that stress lead to a hyperactivity of amygdala, which was accompanied by the removal of inhibitory control.However, the contribution of hyperactivity of amygdala to stress-induced neuropsychiatric diseases, such as anxiety and mood disorders, is still dubious.In this review, we will summarize stress-induced various structural and functional alterations in amygdala, including the GABA receptors expression, GABAergic transmission and synaptic plasticity.It may provide new GLOSSY LIPSTICK ROSE FALLS #516 insight on the neuropathologic and neurophysiological mechanisms of neuropsychiatric diseases.